Synthroid: Precision Thyroid Hormone Replacement Therapy
Synthroid
| Product dosage: 100mcg | |||
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| Package (num) | Per pill | Price | Buy |
| 100 | $0.43 | $43.00 (0%) | ๐ Add to cart |
| 200 | $0.35 | $86.00 $70.00 (19%) | ๐ Add to cart |
| 300 | $0.33
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| Product dosage: 125mcg | |||
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| Package (num) | Per pill | Price | Buy |
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| 240 | $0.33 | $98.00 $80.00 (18%) | ๐ Add to cart |
| 360 | $0.31
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| Product dosage: 150mcg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 100 | $0.55 | $55.00 $55.00 (0%) | ๐ Add to cart |
| 200 | $0.44 | $110.00 $88.00 (20%) | ๐ Add to cart |
| 300 | $0.40
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| Product dosage: 200mcg | |||
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| 100 | $0.68 | $68.00 (0%) | ๐ Add to cart |
| 200 | $0.60 | $136.00 $120.00 (12%) | ๐ Add to cart |
| 300 | $0.57
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| Product dosage: 25mcg | |||
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| 360 | $0.16
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| Product dosage: 50mcg | |||
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| 240 | $0.24 | $58.00 (0%) | ๐ Add to cart |
| 360 | $0.18
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| Product dosage: 75mcg | |||
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| 240 | $0.25 | $59.00 (0%) | ๐ Add to cart |
| 360 | $0.23
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Synonyms | |||
Synthroid (levothyroxine sodium) is the most prescribed synthetic thyroid hormone replacement medication in the United States, trusted by endocrinologists for decades. It is specifically formulated to address hypothyroidism by supplementing deficient thyroid hormone levels, thereby restoring metabolic balance. This medication is bioequivalent to the endogenous hormone thyroxine (T4), ensuring predictable pharmacokinetics and consistent therapeutic outcomes. Properly dosed and monitored, Synthroid effectively manages symptoms of thyroid deficiency and normalizes thyroid-stimulating hormone (TSH) levels, supporting overall endocrine health.
Features
- Contains levothyroxine sodium, a synthetic form of thyroxine (T4)
- Multiple dosage strengths available (ranging from 25 mcg to 300 mcg tablets)
- Manufactured with strict quality control to ensure potency and consistency
- Bioequivalent to endogenous thyroid hormone
- Standardized formulation reduces variability in patient response
- Scored tablets for accurate dose splitting when clinically indicated
- Gluten-free and lactose-free formulation
Benefits
- Restores normal metabolic rate, alleviating symptoms like fatigue, weight gain, and cold intolerance
- Normalizes serum TSH levels, providing a reliable biomarker for treatment efficacy
- Reduces risk of long-term complications associated with untreated hypothyroidism, such as cardiovascular disease and myxedema
- Improves cognitive function, mood stability, and overall quality of life
- Supports normal growth and development in pediatric patients with congenital hypothyroidism
- Offers predictable absorption and stable serum levels when administered correctly
Common use
Synthroid is primarily indicated for the treatment of hypothyroidism, a condition characterized by inadequate production of thyroid hormone by the thyroid gland. It is also used as suppressive therapy in the management of certain thyroid cancers and euthyroid goiters. In some cases, it may be administered as replacement therapy following surgical thyroidectomy or radioactive iodine ablation. Off-label uses are minimal and strictly at the discretion of a qualified healthcare provider based on clinical evidence.
Dosage and direction
Dosage is highly individualized based on clinical status, age, body weight, and TSH levels. Initiation typically begins with a low dose, gradually titrated upward at 4โ6 week intervals based on periodic TSH testing. Adults under 50 with no cardiac history may start with 50โ100 mcg daily; older adults or those with cardiac disease often begin with 12.5โ25 mcg daily. Administer Synthroid orally, as a single daily dose, on an empty stomach at least 30โ60 minutes before breakfast. Tablets should be taken with a full glass of water to ensure proper esophageal passage. Do not crush or chew.
Precautions
Periodic monitoring of TSH levels is essential to avoid under- or over-treatment. Use with caution in patients with cardiovascular disease, adrenal insufficiency, or diabetes mellitus. Thyroid hormone therapy may exacerbate underlying cardiac conditions, including angina or arrhythmias. In patients with diabetes, monitor glycemic control closely as thyroid hormone may affect insulin requirements. Pregnancy alters thyroid hormone้ๆฑ; dose adjustments are often necessary and should be guided by trimester-specific TSH reference ranges.
Contraindications
Synthroid is contraindicated in patients with uncorrected adrenal insufficiency, untreated thyrotoxicosis, or acute myocardial infarction. It should not be used for weight loss in euthyroid patients. Hypersensitivity to any component of the formulation is a absolute contraindication.
Possible side effect
Most adverse effects are dose-related and reflect symptoms of hyperthyroidism if dosage is excessive. Common side effects may include palpitations, tachycardia, weight loss, insomnia, tremors, headache, and increased appetite. Less frequently, patients may experience sweating, heat intolerance, menstrual irregularities, or hair loss. Allergic reactions are rare but may present as rash, urticaria, or pruritus.
Drug interaction
Numerous drugs and supplements may alter the absorption or metabolism of levothyroxine. Calcium carbonate, iron supplements, proton pump inhibitors, bile acid sequestrants, and sucralfate may significantly reduce absorption if taken concurrently. Estrogen-containing medications may increase thyroxine-binding globulin, necessitating dose adjustment. Drugs such as phenytoin, carbamazepine, and rifampin may increase hepatic metabolism of levothyroxine. Always separate administration of Synthroid and interacting agents by at least 4 hours.
Missed dose
If a dose is missed, it should be taken as soon as remembered on the same day. If it is nearly time for the next dose, skip the missed dose and resume the usual dosing schedule. Do not double the dose to make up for a missed one. Consistency in daily administration is critical to maintaining stable hormone levels.
Overdose
Symptoms of overdose resemble those of hyperthyroidism and may include tachycardia, cardiac arrhythmias, chest pain, tremors, restlessness, confusion, and fever. In severe cases, thyroid storm may occur, which is a medical emergency. Treatment is supportive and symptomatic; beta-blockers may be used to control adrenergic symptoms. Consider reducing or withholding levothyroxine until symptoms resolve.
Storage
Store Synthroid tablets at controlled room temperature (20ยฐโ25ยฐC or 68ยฐโ77ยฐF), in a dry place, protected from light and moisture. Keep the bottle tightly closed. Do not store in bathroom cabinets or other humid areas. Keep out of reach of children and pets.
Disclaimer
This information is intended for educational purposes and does not replace professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider for personalized recommendations. Do not initiate, adjust, or discontinue medication without clinical supervision.
Reviews
Clinical studies and decades of use support the efficacy and safety of Synthroid when used as directed under medical supervision. Patients report significant improvement in energy levels, mental clarity, and overall well-being with appropriate dosing. Consistency in brand formulation is often cited as an advantage over generic alternatives in maintaining stable TSH levels. Always discuss treatment experiences and any side effects with your prescribing physician.